Gene Duplication

Vertebrates originated in the lower Cambrian. Their diversification gene morphological dating have been attributed to large-scale gene or for duplications at the origin of gene group. Under such models, gene genes that are duplicated in all vertebrates should have originated during the same period. Previous work has shown that indeed duplications started after the speciation between vertebrates and dating closest invertebrate, amphioxus, duplications have not set a clear ending. Consideration of chordate phylogeny immediately shows the key position gene cartilaginous vertebrates Chondrichthyes to answer this question. Although the time interval is relatively short, it is crucial to understanding the events at the origin of vertebrates. Our results support rounds of dating or genome duplications during a duplications dating of early vertebrate evolution and allow a better characterization of these events. Vertebrates originated in the program Cambrian Shu et al.


Microduplications are changes in chromosomes where small segments of DNA are copied or duplicated. This alters the translation of gene into protein, causing a loss of function. Frameshift mutations resulting from microduplications cause as many as different diseases, including limb-girdle muscular dystrophy, Hermansky-Pudlak syndrome, and Tay-Sachs. Most of these techniques require both generating a break of the DNA strands at the defective gene and the introduction of corrective genetic material.

The new sequence is inserted into the break and repaired by an innate DNA repair mechanism found in cells known as the homology-directed repair pathway. Though therapeutically promising, this method of correcting genes can be inefficient and has other technical challenges.

Gene duplication is postulated to have played a major role in the evolution of biological novelty. S and its edge times, thus dating speciations.

Tick-host-pathogen Interactions View all 39 Articles. Ticks modulate their hosts’ defense responses by secreting a biopharmacopiea of hundreds to thousands of proteins and bioactive chemicals into the feeding site tick-host interface. These molecules and their functions evolved over millions of years as ticks adapted to blood-feeding, tick lineages diverged, and host-shifts occurred. The evolution of new proteins with new functions is mainly dependent on gene duplication events.

Central questions around this are the rates of gene duplication, when they occurred and how new functions evolve after gene duplication. The current review investigates these questions in the light of tick biology and considers the possibilities of ancient genome duplication, lineage specific expansion events, and the role that positive selection played in the evolution of tick protein function. It contrasts current views in tick biology regarding adaptive evolution with the more general view that neutral evolution may account for the majority of biological innovations observed in ticks.

A parasitic blood-feeding lifestyle entails interaction with the vertebrate host, necessitating the evolution of mechanisms to ensure successful acquisition of a blood meal, described as the four stages of blood-feeding evolution Figure 1 , namely: host-detection, host-attachment, host-interaction, and blood meal processing Mans,

NOTUNG: Dating gene duplications using gene family trees

The population genetic mechanisms governing the preservation of gene duplicates, especially in the critical very initial phase, have remained largely unknown. Here, we demonstrate that gene duplication confers per se a weak selective advantage in scenarios of fitness trade-offs. Through a precise quantitative description of a model system, we show that a second gene copy serves to reduce gene expression inaccuracies derived from pervasive molecular noise and suboptimal gene regulation.

We then reveal that such an accuracy in the phenotype yields a selective advantage in the order of 0.

Duplicate genes were preferentially retained for specific functions, such as Dating Whole Genome Duplication in Ceratopteris thalictroides and Potential.

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Duplication, Rearrangement, and Reconciliation

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Date: May 3, ; Source: The Scripps Research Institute; Summary: Scientists have shown that an extra copy of a brain-development gene, which appeared in​.

Metrics details. The sharp increase of plant genome and transcriptome data provide valuable resources to investigate evolutionary consequences of gene duplication in a range of taxa, and unravel common principles underlying duplicate gene retention. We survey sequenced plant genomes to elucidate consequences of gene and genome duplication, processes central to the evolution of biodiversity.

Genes derived from whole-genome, tandem, proximal, transposed, or dispersed duplication differ in abundance, selection pressure, expression divergence, and gene conversion rate among genomes. The number of WGD-derived duplicate genes decreases exponentially with increasing age of duplication events—transposed duplication- and dispersed duplication-derived genes declined in parallel. In contrast, the frequency of tandem and proximal duplications showed no significant decrease over time, providing a continuous supply of variants available for adaptation to continuously changing environments.

NOTUNG: A Program for Dating Gene Duplications and Optimizing Gene Family Trees

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The dating analyses were performed for each gene tree. The dates of gene duplications for the ancestral node of Cornus from these gene trees.

Comparative Genomics pp Cite as. A method to account for gene order data from N genomes according to a given species tree, with no restriction on the number of approximate copies of a gene or of members of a gene family in a genome. Gene orders, together with gene trees produced by sequence comparison, are submitted to an analysis that integrates the concepts of phylogenetic reconciliation, exemplar strings and breakpoint medians.

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Rates and patterns of gene duplication and loss in the human genome

Vertebrates originated in the lower Cambrian. Their diversification and morphological innovations have been attributed to large-scale gene or genome duplications at the origin of the group. Under such models, most genes that are duplicated in all vertebrates should have originated during the same period. Previous work has shown that indeed duplications started after the speciation between vertebrates and the closest invertebrate, amphioxus, but have not set a clear ending.

Consideration of chordate phylogeny immediately shows the key position of cartilaginous vertebrates Chondrichthyes to answer this question. Although the time interval is relatively short, it is crucial to understanding the events at the origin of vertebrates.

This study used a phylogeny of yeast species to date gene duplications, which enabled the authors to estimate the rate of duplications in the.

Duplicate genes are important in disease, are a hugely important source of evolutionary novelty, and for many years we thought we understood them. We thought that duplication relieved selective constraints. We thought that gene knockout neutrality was due to redundancy. We thought that a duplicate is a duplicate is a duplicate. Evidence is accumulating challenging each of these views. Rather than being the result of an unbiased process, the genes that tend to duplicate in our genome and others are quickly evolving, non-essential genes, irrespective of current duplication status.

Conversely, genes retained after whole genome duplication WGD are slowly evolving, important genes. I propose that different resolution of the evolutionary constraints imposed by the demands of gene expression can explain these contrasting relationships. I propose that the opposing constraints on gene-by-gene duplications as compared to WGD channel these different sets of genes into remarkably different evolutionary trajectories.

In particular, in much the same way that individual gene duplication creates an opportunity for the evolution of a new gene, the co-evolution of expression of sets of interacting genes after WGD creates an opportunity for the evolution of new biochemical pathways and protein complexes. Furthermore, I suggest a common mechanism of pathogenicity for many duplication events independent of the biochemical function of the encoded genes.

With the availability of abundant high-quality genomics data, now is an opportune time to address these questions. Primarily through computational and statistical analysis I will reveal the relationship between gene duplication and expression and test a model that the indirect costs of gene expression are a major determinant of the outcome of gene duplication.

I will explore the effects this has on gene and genome evolution.

Gene Duplication and Protein Evolution in Tick-Host Interactions

Through phylogeny reconstruction we identified 49 genes with a single copy in man, mouse, and chicken, one or two copies in the tetraploid frog Xenopus laevis , and two copies in zebrafish Danio rerio. For 22 of these genes, both zebrafish duplicates had orthologs in the pufferfish Takifugu rubripes. For another 20 of these genes, we found only one pufferfish ortholog but in each case it was more closely related to one of the zebrafish duplicates than to the other.

Forty-three pairs of duplicated genes map to 24 of the 25 zebrafish linkage groups but they are not randomly distributed; we identified 10 duplicated regions of the zebrafish genome that each contain between two and five sets of paralogous genes. Ohno proposed that without duplicated genes the creation of metazoans, vertebrates and mammals from unicellular organisms would have been impossible Ohno Such big leaps in evolution, Ohno argued, required the creation of new gene loci with previously nonexistent functions.

Furthermore, dating individual gene families does and (by inference) genome duplication dates.

A search for RNA insertions and NS3 gene duplication in the genome of cytopathic isolates of bovine viral diarrhea virus V. Quadros, S. Mayer, F. Vogel, R. Weiblen, M. Brum, S. Arenhart and E. Calves born persistently infected with non-cytopathic bovine viral diarrhea virus ncpBVDV frequently develop a fatal gastroenteric illness called mucosal disease. Cytopathic BVDVs originate from their ncp counterparts by diverse genetic mechanisms, all leading to the expression of the non-structural polypeptide NS3 as a discrete protein.

In contrast, no detectable NS insertions or NS3 gene duplications were observed in the genome of 37 cp isolates.

What is Duplication, Replication and DeDuplication – Explained in just 3 Minutes